Consultant

Dr Dionysis Papadatos-Pastos

Consultant Oncologist
MD MRCP(UK) PhD
Headshot of consultant Dionysis Papadatos-Pastos

Dr. Papadatos-Pastos is a distinguished oncologist specialising in lung cancer, mesothelioma, thymoma, and thymic cancer. With an extensive publication record in leading medical journals, he is a sought-after speaker and contributor to national and international conferences. Dr. Papadatos-Pastos adopts a multidisciplinary approach to deliver personalised and comprehensive care for his patients.

Medical oncology, Thoracic cancers
English, Greek
In-person, Phone call, Video call
New £375 (follow-up £275)
 

Bio

Dr. Dionysis Papadatos-Pastos

Dr Dionysis Papadatos-Pastos is a highly experienced thoracic oncologist with over 20 years of expertise in lung cancer, mesothelioma, thymoma, and thymic cancer. He is committed to combining medical excellence with compassionate, patient-centred care.

Dr. Papadatos-Pastos graduated in medicine from the University of Athens with distinction, which was followed by his PhD in medical oncology (focusing on biomarkers) in 2012 with First Class honours. He trained in medical oncology at top UK cancer centres and completed a fellowship at the Royal Marsden’s phase I clinical trials unit. His work focused on advancing targeted therapies and immunotherapy combinations for non-small cell lung cancer, small cell lung cancer, and mesothelioma. He was awarded a diploma in medical oncology from the Institute of Cancer Research at the University of London.

He leads the lung cancer program at the CRUK UCL Clinical Trials Centre and co-chairs the London Clinic Lung Cancer MDT, where he develops individualised treatment plans through a multidisciplinary approach.

Dr Papadatos-Pastos is an avid researcher and has been the principal investigator on multiple academic and commercial clinical trials. In 2010 he received the ASCO Merit Award. His research, which is published in leading journals, emphasises personalised treatment strategies using immunotherapy and targeted approaches.

He has also presented at conferences, nationally and worldwide. His topics of research include the development of novel targeted therapies for the treatment of lung cancer, and assessing combinations of immunotherapy drugs with other anti-cancer compounds. 

Outside work, he mentors junior doctors, enjoys swimming, and values time with his family.  

Areas of expertise

  • Non-small cell lung cancer
  • Small cell lung cancer
  • Mesothelioma
  • Thymoma
  • Thymic cancer 
What sets me apart from conventional approaches, is my focus on personalised, research-driven care. I develop tailored treatment plans based on each patient’s clinical profile, working closely with specialists across the multi-disciplinary team to ensure a comprehensive and targeted approach. Unlike standard treatment models, my experience as a clinical researcher allows me to integrate novel therapies from early-stage clinical trials into practice, offering patients access to cutting-edge treatments. This combination of multidisciplinary collaboration, research expertise, and individualised care allows me to deliver more precise and effective treatment strategies than conventional oncology practices.
Dr Dionysis Papadatos-Pastos

More information

146 Harley Street

London, W1G 7JL

  • ASCO Merit Award 2010
  • Qualified 2002
  • National and Kapodistrian University of Athens 1995-2002
  • Consultant in Medical Oncology
    University College London Hospitals
  • Consultant in Medical Oncology
    The Princess Alexandra Hospital

Articles

Article: Living with Purpose: Lynda’s Journey with Cancer

Research

As the Principal Investigator of the HyPeR clinical trial (NIHR UCLH Clinical Research Facility), Dr Papadatos-Pastos leads efforts to understand and overcome resistance to immunotherapy in lung cancer. The trial is investigating the mechanisms behind immunotherapy resistance and explores whether adding a novel drug to immunotherapy can reverse this resistance and improve outcomes. Early results have been encouraging, demonstrating potential to enhance treatment response. These findings have been published in a respected oncology journal, highlighting the trial’s clinical significance. Dr Papadatos-Pastos continues to oversee patient enrolment, treatment protocols, and data analysis, aiming to refine and expand immunotherapy options for lung cancer patients.

  • RCP
  • MDU

Dr Papadatos-Pastos has been featured in print publications such as The Guardian, The Evening Standard and Cosmopolitan UK.

Lung Care

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You can visit the Lung Centre website to explore your options, or call our team directly to book an appointment.

A patient (model) using a Linac MRI machine to scan her lungs
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