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Groundbreaking new antibody therapy at The London Clinic offers lung cancer patients new hope

31 Oct 2025

Another pioneering first as The London Clinic rolls out antibody therapy (Tarlatamab) immunotherapy

Small cancer tumors on the lung tissue: lung cancer (LC) – isometric view 3d illustration
An isometric view 3D illustration of small cell cancer tumours on the lung tissue

A ground-breaking therapy to treat an aggressive type of lung cancer in patients has been administered for the first time to a patient, under the care of leading thoracic oncologist, Dr Dionysios Papadatos-Pastos and his team.

Lung cancer specialist Dr Dionysios Papadatos-Pastos, said he was delighted The London Clinic was the first private hospital to offer bispecific antibody therapy (Tarlatamab) to a patient, who received it earlier this year.

He explained, “Our first patient started Tarlatamab after their cancer had worsened despite two previous rounds of chemotherapy. Treatment options were very limited, but after just a few infusions of Tarlatamab, scans showed the tumours had shrunk significantly. The patient experienced only mild side effects and is maintaining a good quality of life throughout treatment.

“Tarlatamab has been shown to work better than traditional chemotherapy for patients whose cancer has progressed after initial treatment. It needs to be given in a specialist centre experienced with these advanced therapies, and we’re proud that The London Clinic was the first independent hospital in the UK to offer this ground-breaking treatment to eligible patients.”

For patients with small cell lung cancer, treatment options can become very limited once the cancer returns after initial therapy.  

Tarlatamab is a new type of cancer treatment that helps the body’s own immune system find and attack small cell lung cancer cells. It works like a bridge, connecting the cancer cells (which have a marker called DLL3) to immune cells (called T cells) so they can destroy the cancer. In simple terms, it trains the immune system to better recognise and kill hidden cancer cells.

I recently attended the ESMO (European Society for Medical Oncology) 2025 Congress in Berlin, where I had the chance to discuss the latest results on Tarlatamab with colleagues from around the world. The new data confirms what we’re seeing in practice — that Tarlatamab is an effective and well-tolerated treatment, bringing new hope to patients with small cell lung cancer.
Dr Dionysios Papadatos-Pastos

The London Clinic is a world leader in the private treatment and care of people diagnosed with cancer and their families. The award-winning Duchess of Devonshire Wing is one of the most modern and technologically advanced cancer hospitals in the UK.

A photo of the team at the London Clinic who launched the new antibody therapy lung cancer treatment. Smiling and happy looking at camera celebrating success
Left to right: Andie Guy, Dr Sanya Arora, Dr Dionysis Papadatos-Pastos, Dr Sam Marks, Ralph Basilio
Headshot of CNS, Laura Falconer
Laura Falconer, Clinical Nurse Specialist, was also part of the team that launched Tarlatamab
Lung Care

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Looking for expert support with a lung condition, diagnosis or treatment? The London Clinic Lung Centre has its own dedicated website to help you find the care you need, fast. From lung cancer to complex lung conditions, you’ll find world-class consultants, same-day diagnostic appointments and personalised treatment plans — all in one place.

You can visit the Lung Centre website to explore your options, or call our team directly to book an appointment.

A patient (model) using a Linac MRI machine to scan her lungs
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