Lutetium-177 PSMA for advanced prostate cancer

PSMA therapy, chemotherapy alternative for prostate cancer

Lutetium-177 PSMA is a new type of cancer treatment for advanced prostate cancer. By precisely seeking out and destroying cancer cells, it reduces damage to your healthy cells so you can recover faster.


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What is it for?

Treating advanced prostate cancer

Treatment overview

Advanced prostate cancer (metastatic prostate cancer) is a cancer that spreads from the prostate to other parts of the body, and most commonly the bones. 

Lutetium-177 PSMA is an innovative new treatment that involves a special radioactive medication being injected into your bloodstream.

Inside your body, the medication seeks out prostate cancer cells and tightly attaches to them. It then precisely delivers a high dose of radiation to destroy the cancer cells.

Usually, most people have four treatments with lutetium-177 PSMA, with three-month breaks between each treatment.

At The London Clinic, your treatment with lutetium-177 PSMA will be overseen by world-leading nuclear medicine and oncology consultants.

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Your consultant may recommend lutetium-177 PSMA to you if: 

  • You’ve already had chemotherapy, or are unable to do so
  • You’ve already received a new hormonal therapy such as enzalutamide or abiraterone

Lutetium-177 PSMA is one of several treatment options we offer for advanced prostate cancer.

Your consultant may also recommend one or more of the following treatments, depending on your age, general health and the stage or grade of your prostate cancer.

  • Chemotherapy
  • External beam radiotherapy (EBRT)
  • Hormone therapy

Why choose The London Clinic

Excellence in one place

We operate as teams of experts with world-class resources dedicated to maintaining the highest standards of medical care. You are surrounded by the latest treatments and advice with everything you need to get back to your best health.

Personal care, every time

Exceptional patient care is a way of life for us. Our nurses, clinicians and support teams are dedicated to the care of a very small number of patients, so have more time for you. They’ll be with you every step of the way, tailoring your care around you and giving the peace-of-mind that comes with knowing you’re in the best hands.

Effortlessly simple

We work together as one to guide you through each step of your experience, with complexities unravelled and answers readily to hand. Your personal treatment plan will be laid out for you, with all the details taken care of so you can focus on you.

What's included in your package?

Choosing The London Clinic means your treatment plan will be laid out for you, with all the details taken care of so you can focus on you.


Your treatment package will include:

  • Enhanced pre-admission assessment
  • Your treatment with our complete care team at your fingertips
  • Personalised aftercare and follow-up

We want you to be in control of your health. That’s why we also offer optional services such as comprehensive recovery packages and extra touches for you to choose from during your stay with us.

How to pay

  • You can use private medical insurance (PMI) to access this treatment. We work with all major PMI providers in the UK and many internationally
  • You can pay for yourself (self-pay)
  • If you’re paying for yourself, we have finance options available with Chrysalis


We aim to get you treated without delay and back to your normal life as quickly as possible. Typically, this involves the following steps:

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Book an appointment

Our dedicated appointments team will arrange for you to meet with one of our renowned consultants.

Diagnosis and treatment plan

At your appointment, your consultant will review your medical history and current health. They’ll discuss the benefits and side effects of lutetium-177 PSMA therapy with you too.

The day of your treatment

Your care team will welcome you, talk you through the day ahead and get you ready for your treatment. 


You’ll receive your lutetium-177 PSMA therapy and remain in your room for the day, where you’ll be made as comfortable as possible. 


After your treatment, your consultant will find out how you’re feeling and discuss your recovery plan.


You'll stay at The London Clinic until you've recovered well from your treatment. We’ll also give you advice about radiation safety and possible side effects.


Your consultant will have follow-up appointments with you to check everything is going as expected and you're recovering well. 


At these meetings, you’ll also have time to ask any questions or speak about any concerns.


Prostate cancer cells feature substances that your doctors may refer to as markers.

One such marker is a type of protein called PSMA (prostate-specific membrane antigen). 

When lutetium-177 is injected into your bloodstream, it specifically seeks out cells that feature PSMA and tightly sticks to them. 

The damaging radiation in lutetium-177 then kills the prostate cancer cells over time, while causing minimal damage to healthy cells nearby.

Many people treated with lutetium-177 PSMA therapy have a positive response to it, for example, the signs and symptoms of your cancer may be reduced. 

However, because PSMA is a new treatment, we’re still learning about all the benefits it offers.

The most common side effect of PSMA therapy is a dry mouth and dry eyes, and mild lethargy (lack of energy). 

Sometimes, you may experience nausea or vomiting as a side effect. 

Most of these side effects only last for a short time and are usually gone after a few days. 

If you had extensive cancer in your bones when you were treated, the amount of marrow in your bones may be reduced. 

This may mean you need a blood transfusion to help you recover.

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