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OUR CLINICAL TRIALS AND OUR RELATIONSHIP WITH EMINENT CONSULTANTS

The Charity supports a dedicated clinical trials unit, the Advanced Therapies Centre (ATC) who provide a phase I and IV clinical trials program. This provides patients with access to treatments through clinical trials with new medicines, medical devices and health technologies. In addition to special access programs approved by the MHRA for early access to specialized clinical procedures, which are often not available elsewhere and drive forward research in these areas for public benefit generally.

The ATC has hosted or sponsored 11 research projects treating 167 patients throughout 2017. The team provide Research Governance, TLC Ethics committee updates and Quality Assurance. Principal Investigator (Consultant) support from study set up, on study management and facilitate collaboration with seven NHS hospitals, universities and charities.

Our trial portfolio extends from advanced medicinal products, derived from stem cell collection, to simple bench top research using tissue and blood samples provided from London Clinic patients to assist medical research for future generations. The ATC has passed various sponsor site audits for compliance to study protocol and Good Clinical Practice (GCP), confirming we met all the regulatory requirements and maintain a high standard of quality in our clinical trials team.

Annual Research Activity

Graph showing the annual research activity at The London Clinic

Our current studies

TITLE

INVESTIGATOR
SPONSOR

TRIAL TYPE STATUS WEBSITE
BioPoly RS prosthesis (ATC_005)
Multi-centre, open label, prospective, consecutive series registry database of BioPoly™ RS Partial Resurfacing Knee Implant

Mr. Nathwani

Schwartz Biomedical, LLC

Medical Device (CE marked)  Closed to enrolment BioPoly RS Knee Registry Study for Cartilage Defect Replacement
ConforMIS iUni G2 Partial Knee Prosthesis (ATC_022)
A Prospective, Multi-Centre study to Evaluate the ConforMIS iUni G2 Unicompartimental Knee Resurfacing Device

Mr Nathwani

ConforMIS

Medical Device (CE marked)  Closed to enrolment

iUni G2+ Prospective Study

TARGIT R (ATC_034)
TARGIT R: Initiation and maintenance of a registry database of patients treated with targeted intraoperative radiation therapy using Intrabeam (TARGIT) following breast conserving surgery for early breast cancer.

Mr Gui

University College London (UCL) Surgical & Interventional Trials Unit

Medical Device (CE marked)  Ongoing enrolment

TARGIT R: TARGeted Intraoperative radioTherapy (TARGIT) Registry database

RADIOCYST (ATC_040)
A phase II multicentre study of endoscopic ultrasound guided radiofrequency ablation of cystic tumours of the pancreas

Prof. Pereira

University College London (UCL) Surgical & Interventional Trials Unit

Medical Device (CE marked)  Ongoing enrolment

A Phase II Multicentre Trial of Endoscopic Ultrasound Guided Radiofrequency Ablation of Cystic Tumours of the Pancreas (RDIOCYST01)

BioPoly™ RS Patella Registry Study (ATC_041)
Open label, prospective, consecutive series registry database of BioPoly RS Partial Resurfacing Patella Implant

Mr. Nathwani

Schwartz Biomedical, LLC

Medical Device (CE marked)  Ongoing enrolment

BioPoly® RS Partial Resurfacing Patella Registry Study

ReadyfusOR health economics (ATC_047)
Pilot healthcare economics and observational study of the OneDose ReadyfusOR (a factory-filled infusion device delivering a continuous infusion of ropivacaine 2mg/ml for up to 48 hours), for the treatment of post-operative pain in patients who have undergone open intra-abdominal surgery (laparotomy)

Prof.  Richard Langford

BioQ Pharma Incorporated

Combination medication and Medical Device (CE marked) Ongoing enrolment

Readyfusor health economics study

NCEPOD (ATC_055)
Study to identify and explore remediable factors in the process of care in the peri-operative management of surgical patients with diabetes

Phillip Yeoh

NCEPOD

Non IMP trial for national data research. Enrolment closed and patient data analysis starting at NCEPOD

Perioperative Diabetes

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