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The London Clinic

Professor Alastair O'Brien is available for video consultations.
For help with this service please contact our Appointments team:
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Professor Alastair O'Brien is a Consultant Hepatologist at The London Clinic, specialising in liver conditions.

Specialties and sub-specialties


Specialist microsites

London Liver Group

Professional profile

Alastair O’Brien is a Professor of Hepatology at University College London and The Royal Free Hospitals. He runs a successful research group focused on infection and immune dysfunction in liver disease.

His work has been published in the most prestigious medical Journals such as The Lancet, The New England Journal of Medicine, Nature Medicine, Hepatology and Gastroenterology.

He currently holds approximately £4m in grant funding from the Wellcome Trust, The Medical Research Council and National Institute for Health Research. He is able to combine clinical excellence with running a laboratory research group and a clinical trial team. 

He is the chief investigator for the ATTIRE trial (Albumin To prevenT Infection in chronic liveR failurE) which recently completed and is the largest trial in advanced liver disease worldwide over the last 5 years. The results will be published in 2020.

His team has just started another large scale trial of antibiotic prophylaxis to prevent infection in patients with cirrhosis.

He is also the associate editor for the British Medical Journal open Gastroenterology and has written the hepatology chapter for the best-selling medical textbook Kumar and Clarke’s Clinical Medicine, 9 and 10th Edition and joint-authored the prize-winning Kumar and Clarke’s Clinical Medicine handbook. 

Dr O’Brien is a great advocate of patient choice and believes that empathy and listening to people are a doctor’s most important duties.

Clinical interests

  • Alcohol
  • Abnormal liver enzymes
  • Fatty liver disease
  • Viral hepatitis
  • General gastroenterology
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  • Intensive care management of liver disease patients
  • Autoimmune and Metabolic liver disease
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Current posts

  • Clinical Senior Lecturer and Consultant Hepatologist
    University College London and The Royal Free Hospitals

Medical training

Year qualified 1994
  • United Medical and Dental Schools of Guy’s and St Thomas’s Hospitals 1994


100 Days Dry Challenge: Final Orders
Dr O'Brien uses a FibroScan® test to measure the impact of not drinking alcohol for a prolonged period.
This is what happens to your body after all the heavy drinking at Christmas
Dr O'Brien is extensively quoted on the physical drawbacks of drinking alcohol.

Personal interests

Dr O’Brien is a fitness fanatic but most of all enjoys spending time with his wife and two gorgeous children.